Selectins.
نویسندگان
چکیده
منابع مشابه
Selectins with a catch
Small minerals make strong bones Selectins with a catch ot content simply with a good fit, evolution has apparently designed adhesion molecules that stick optimally only when tugged upon. This property, may stop leukocytes and platelets from lingering in stagnant backwaters in the blood where there is little or no flow. Blood is a medium dominated by flow and shear forces. " If you think flow i...
متن کاملSelectins promote tumor metastasis.
Cancer metastasis is facilitated by cell-cell interactions between cancer cells and endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and leukocytes contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Selectins are carbohydrate-binding molecules that bind to sialylated, fucosylated glycan structures, and are fo...
متن کاملSelectins: critical mediators of leukocyte recruitment.
Selectins are multi-functional adhesion molecules that mediate the initial interactions between circulating leukocytes and the endothelium. First identified over a decade ago, selectins have provided insight into areas as diverse as normal lymphocyte homing, leukocyte recruitment during inflammatory responses, carbohydrate ligand biosynthesis and adhesion-mediated signalling. This review will e...
متن کاملTargeting Selectins and Their Ligands in Cancer
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune cell evasion, drug evasion, drug resistance, tumor invasiveness, and vascular dissemination, leading to metastases. Hypersialylation of cancer cells is largely the result of ...
متن کاملThe role of selectins in alopecia areata
INTRODUCTION One of the main histopathological features of alopecia areata (AA) is a lymphocytic infiltration that surrounds hair follicles. Soluble forms of E, L, P-selectins are known indicators of ongoing inflammation. There are no studies regarding the assessment of their contribution in AA. AIM To assess serum concentrations of selectins (E-selectin, L-selectin and P-selectin) in patient...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1993
ISSN: 0021-9738
DOI: 10.1172/jci116210